Allergic diseases of the skin and drug allergies – 2014. Predictive value of clinical history in suspcicion of quinolones hypersensitivity

Results We studied 78 patients, 55 (70%) female, the mean age was 50 years. Urticaria (26%) and maculo-papular exanthema (20%) were the most frequent manifestations; anaphylaxis was reported in 27% of cases. Ciprofloxacin (36%), Ofloxacin (20%) and Levofloxacin (18%) were the most frequent suspected drugs. Forty-one (52%) patients presented the manifestations in the first hour after the intake of the drug. The diagnosis was confirmed in 30 (39%) patients, 24 (80%) were by drug provocation test (DPT). The concordance between the symptoms referred in the clinical history and the manifestations of positive DPT was of 71%. Positivity occurred in 20 (67%) patients who experienced immediate reactions and in 10 (29%) with non-immediate reactions. The specificity of the clinical history of QH was 15% and its positive predictive value (PPV) was 42%. The PPV for those who experienced urticaria was 43% and for maculo-papular exanthema, 25%; while it was 70% for the patients who reported anaphylaxis.